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CD33 splice site genotype was not associated with outcomes of patients receiving the anti-CD33 drug conjugate SGN-CD33A

Abstract We tested whether a single nucleotide polymorphism (SNP) that affects splicing of CD33 predicted response to treatment in adults with acute myeloid leukemia (AML) who received the novel CD33 antibody-drug conjugate SGN-CD33A. This genotype, for the CD33 splice site SNP rs12459419, was not a...

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Bibliografski detalji
Glavni autori: Michele Stanchina, Alessandro Pastore, Sean Devlin, Christopher Famulare, Eytan Stein, Justin Taylor
Format: Artigo
Jezik:Inglês
Izdano: BMC 2019-08-01
Serija:Journal of Hematology & Oncology
Teme:
Online pristup:http://link.springer.com/article/10.1186/s13045-019-0771-0
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