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Does Kappa Agonism Improve Reversal of ‘Tranq-Dope’ Overdose? Evidence from a Rodent Model

<b>Background/Objectives</b>: The recreational use of fentanyl (FT) combined with xylazine (XZ), known as “tranq-dope,” poses a growing public health threat due to its high toxicity and mortality. This study evaluated the effectiveness of naloxone (NX), its lipophilic prodrug NX90, and their combina...

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Principais autores: Michael Voronkov, Mihai Cernea, Cristina Stefanut, Georgiy Nikonov, George Milevich, John Abernethy
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2026-05-01
Serier:Pharmaceuticals
Fag:
opioid use disorder
fentanyl
xylazine
overdose
polysubstance use
Online adgang:https://www.mdpi.com/1424-8247/19/6/846
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