Discoidin domain receptors promote α1β1- and α2β1-integrin mediated cell adhesion to collagen by enhancing integrin activation.

The discoidin domain receptors, DDR1 and DDR2, are receptor tyrosine kinases that bind to and are activated by collagens. Similar to collagen-binding β1 integrins, the DDRs bind to specific motifs within the collagen triple helix. However, these two types of collagen receptors recognize distinct col...

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Үндсэн зохиолчид:	Huifang Xu, Dominique Bihan, Francis Chang, Paul H Huang, Richard W Farndale, Birgit Leitinger
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Public Library of Science (PLoS) 2012-01-01
Цуврал:	PLoS ONE
Онлайн хандалт:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0052209&type=printable
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