Identification of key amino acids defining conformational neutralizing epitopes of coxsackievirus A5 using monoclonal antibody escape mutants

BackgroundCoxsackievirus A5 (CVA5) is an emerging pathogen associated with severe hand, foot, and mouth disease. Protective antibodies are critical for protection from CVA5 infection, yet the antigenic determinants of CVA5 remain poorly defined. In this study, we aimed to map the conformational neut...

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Detalhes bibliográficos

Principais autores:	Ke Xu, Jie Pei, Chen Wang, Jing Guo, Xiao-Qi Chen, Shuo Shen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-04-01
coleção:	Frontiers in Immunology
Assuntos:	antigenic mapping conformational neutralizing epitopes coxsackievirus A5 escape mutants monoclonal antibody
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1837533/full
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