Early life social isolation stress and pain vulnerability: unraveling neuroimmune mechanisms and central sensitization

Chronic pain is increasingly recognized as a multidimensional condition in which neuroimmune interactions shape disease vulnerability and persistence. Among the emerging pain phenotypes, nociplastic pain (defined as an alteration of nociceptive processing in the absence of clear tissue damage or som...

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Detalhes bibliográficos

Principais autores:	Carmela Belardo, Maria Consiglia Trotta, Federica Ricciardi, Michela Perrone, Andrea Maria Morace, Rebecca Limongelli, Roozbe Bonsale, Erika D’Agostino, Emanuele Di Martino, Antimo Fusco, Silvia Natoli, Francesca Guida, Sabatino Maione, Livio Luongo
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-06-01
coleção:	Frontiers in Pharmacology
Assuntos:	behaviour early-life stress neroimmunity nociplastic pain social isolation
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1844087/full
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