Copper-enriched zinc peroxides induced cuproptosis through concurrent metabolic and oxidative dysregulation for boosting immunotherapy in colorectal cancer

Despite the immunotherapy has achieved the progress for advanced colorectal cancer, the unsatisfactory treatment effect remains a challenge due to the deficient immune response. In this work, we constructed a tumor microenvironments (TME)-responsive biodegradable cuproptosis inducer (ZnO2-Cu@HA, ZCH...

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Autori principali:	Shaopeng Zhang, Shaokang Yang, Mingqi Li, Hao Zhang, Yue Cao, Shiqi Bai, Wei Li, Bin Wang, Donghao Qu, Ziqian Wang, Wanying Li, Yanxu Sun, Daguang Wang, Yinghui Wang, Hongjie Zhang
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2026-04-01
Serie:	Materials Today Bio
Soggetti:	Colorectal cancer Cuproptosis Glycolysis Immunotherapy Nanomedicine
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2590006426000736
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