Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation

Abstract Atrial fibrillation (AF) is a common cardiac arrhythmia with strong genetic components, yet its underlying molecular mechanisms and potential therapeutic targets remain incompletely understood. We conducted a cross-population genome-wide meta-analysis of 252,438 AF cases and identified 525...

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Auteurs principaux:	Shuai Yuan, Jie Chen, Xixin Ruan, Yuying Li, Sarah A. Abramowitz, Lijuan Wang, Fangyuan Jiang, Ying Xiong, Michael G. Levin, Benjamin F. Voight, Dipender Gill, Stephen Burgess, Agneta Åkesson, Karl Michaëlsson, Xue Li, Scott M. Damrauer, Susanna C. Larsson
Format:	Artigo
Langue:	Inglês
Publié:	Nature Portfolio 2025-07-01
Collection:	Nature Communications
Accès en ligne:	https://doi.org/10.1038/s41467-025-61720-2
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