Notch signaling drives development of Barrett’s metaplasia from Dclk1-positive epithelial tuft cells in the murine gastric mucosa

Abstract Barrett’s esophagus (BE) is a precursor to esophageal adenocarcinoma (EAC), but its cellular origin and mechanism of neoplastic progression remain unresolved. Notch signaling, which plays a key role in regulating intestinal stem cell maintenance, has been implicated in a number of cancers....

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Detalhes bibliográficos

Principais autores:	Bettina Kunze, Moritz Middelhoff, H. Carlo Maurer, Tatiana Agibalova, Akanksha Anand, Anne-Marie Bührer, Hsin-Yu Fang, Theresa Baumeister, Katja Steiger, Julia Strangmann, Roland M. Schmid, Timothy C. Wang, Michael Quante
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2021-02-01
coleção:	Scientific Reports
Acesso em linha:	https://doi.org/10.1038/s41598-021-84011-4
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