A C-Terminally Truncated TDP-43 Splice Isoform Exhibits Neuronal Specific Cytoplasmic Aggregation and Contributes to TDP-43 Pathology in ALS

Neuronal cytoplasmic aggregation and ubiquitination of TDP-43 is the most common disease pathology linking Amyotrophic Lateral Sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). TDP-43 pathology is characterized by the presence of low molecular weight TDP-43 species generated through prot...

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Principais autores:	Marc Shenouda, Shangxi Xiao, Laura MacNair, Agnes Lau, Janice Robertson
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-06-01
coleção:	Frontiers in Neuroscience
Assuntos:	TARDBP TDP-43 amyotrophic lateral sclerosis frontotemporal lobar degeneration N-terminal fragment C-splice variant
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fnins.2022.868556/full
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