Sigma-1 receptor is involved in degradation of intranuclear inclusions in a cellular model of Huntington's disease

The sigma-1 receptor (SIGMAR1) is one of the endoplasmic reticulum (ER) chaperones, which participate in the degradation of misfolded proteins via the ER-related degradation machinery linked to the ubiquitin–proteasome pathway. ER dysfunction in the formation of inclusion bodies in various neurodege...

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Detalhes bibliográficos

Principais autores:	Yasuo Miki, Kunikazu Tanji, Fumiaki Mori, Koichi Wakabayashi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2015-02-01
coleção:	Neurobiology of Disease
Assuntos:	Sigma-1 receptor Huntington's disease Neuronal nuclear inclusions Ubiquitin–proteasome system Endoplasmic reticulum chaperone Endoplasmic reticulum-associated degradation
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S096999611400343X
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