A single low dose of primaquine is safe and sufficient to reduce transmission of Plasmodium falciparum gametocytes regardless of cytochrome P450 2D6 enzyme activity in Bagamoyo district, Tanzania

Abstract Background Primaquine is a pro-drug and its active metabolite is potent against mature Plasmodium falciparum gametocytes. Primaquine is metabolized by a highly polymorphic cytochrome P450 2D6 (CYP2D6) enzyme. Mutations in the gene encoding this enzyme may lead to impaired primaquine activit...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Richard Owden Mwaiswelo, Billy Ngasala, Dominick Msolo, Eliningaya Kweka, Bruno P. Mmbando, Andreas Mårtensson
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2022-03-01
coleção:	Malaria Journal
Assuntos:	Safety Efficacy Single low-dose primaquine Plasmodium falciparum gametocytes Cytochrome P450 CYP2D6 G6PD deficiency
Acesso em linha:	https://doi.org/10.1186/s12936-022-04100-1
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!