Jichuan decoction alleviates constipation by inhibiting the PI3K/Akt/mTOR signaling pathway: an integrated network pharmacology and experimental study

Abstract Chronic constipation affects approximately 15% of the global population and substantially reduces patients’ quality of life. Jichuan Decoction (JCD), a traditional Chinese medicine (TCM) formulation, has demonstrated clinical efficacy in the treatment of constipation; however, its underlyin...

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Detalhes bibliográficos

Principais autores:	Xiang Bao, Yunyun Chen, Qianying Zhu, Weimin Den, Bo Zhang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2026-03-01
coleção:	Scientific Reports
Assuntos:	Constipation Jichuan decoction Network pharmacology PI3K/Akt/mTOR pathway
Acesso em linha:	https://doi.org/10.1038/s41598-026-42428-9
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