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Mitochondrial quality control as a central pharmacological target in aging

Mitochondrial dysfunction is a convergent hallmark of biological aging and a mechanistically attractive target for gerotherapeutic development. Yet translation of mitochondria-focused interventions has been limited by pathway complexity, tissue heterogeneity, and insufficiently harmonized endpoints....

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Principais autores: Kuan-Hao Tsui, Shih-Hsuan Cheng, Boyang Wang, Pei-Hsuan Lin, Emmanuel Naveen Raj, Li-Te Lin, Renin Chang, Zhi-Hong Wen, Andy P. Tsai, Chia-Jung Li
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2026-05-01
Serier:Pharmacological Research
Fag:
Mitochondrial quality control
Mitophagy
Aging
Metabolism
Translational biomarkers
Online adgang:http://www.sciencedirect.com/science/article/pii/S1043661826001039
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