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Normalization of Oxygen Levels Induces a Metabolic Reprogramming in Livers Exposed to Intermittent Hypoxia Mimicking Obstructive Sleep Apnea

Obstructive sleep apnea (OSA), characterized by intermittent hypoxia (IH), is strongly associated with metabolic syndrome and metabolic dysfunction-associated steatotic liver disease (MASLD). IH exacerbates MASLD progression through oxidative stress, inflammation, and lipid accumulation. This study...

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Main Authors: Miguel Á. Hernández-García, Beatriz Aldave-Orzáiz, Carlos Ernesto Fernández-García, Esther Fuertes-Yebra, Esther Rey, Ángela Berlana, Ramón Farré, Carmelo García-Monzón, Isaac Almendros, Pedro Landete, Águeda González-Rodríguez
Format: Artigo
Language:Inglês
Published: MDPI AG 2025-08-01
Series:Antioxidants
Subjects:
obstructive sleep apnea
CPAP
MASLD
liver steatosis
intermittent hypoxia
steatosis
Online Access:https://www.mdpi.com/2076-3921/14/8/971
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