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Proof-of-concept study of clinical use of blood-based MAVS biosensor in predicting immunotherapy response in SCLC patients

Small cell lung cancer (SCLC) is an aggressive neuroendocrine tumor with poor prognosis and limited benefit from immune checkpoint inhibitors (ICIs). Biomarker-driven patient stratification has been hindered by small biopsy samples, high tumor heterogeneity, and the limited predictive value of PD-L1...

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Principais autores: Luisa Amato, Ines Tavoletta, Caterina De Rosa, Mimimorena Seggio, Francesco Arcadio, Sara Capaldo, Faiz Ul Haq, Concetta Tuccillo, Carla Esposito, Gaetano di Guida, Francesca Iommelli, Viviana De Rosa, Alfonso Reginelli, Salvatore Cappabianca, Floriana Morgillo, Fortunato Ciardiello, Valerio Nardone, Nunzio Cennamo, Carminia Maria Della Corte, Luigi Zeni
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2026-05-01
Serier:Translational Oncology
Fag:
SCLC
Blood-based biomarker
Liquid biopsy
MAVS
Immune sensing
Online adgang:http://www.sciencedirect.com/science/article/pii/S1936523326000938
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