Atorvastatin promotes lipid catabolism in colorectal cancer via FDFT1‒mediated inhibition of the PI3K/AKT pathway

Abstract As a hydroxymethylglutaryl‒coenzyme A reductase (HMGCR) inhibitors, atorvastatin (ATST) has garnered widespread attention because of its antitumor effects. However, its specific mechanism of action remains incompletely understood. In our study, ATST was found to inhibit AOM/DSS‒induced colo...

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Detalhes bibliográficos

Principais autores:	Jiale Xu, Xiaoyu Qin, Longying Xiong, Cheng Zhao, Dan Ge, Yanping Wu, Yixuan Shen, Mengli Yang, Bihan Shen, Min Chen, Chen Min
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-03-01
coleção:	Cell Communication and Signaling
Assuntos:	Atorvastatin Colorectal cancer PI3K/AKT pathway FDFT1 ER stress Lipid catabolism
Acesso em linha:	https://doi.org/10.1186/s12964-026-02802-6
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