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Conversion of Gastrointestinal Somatostatin-Expressing D Cells Into Insulin-Producing Beta-Like Cells Upon Pax4 Misexpression

Type 1 diabetes results from the autoimmune-mediated loss of insulin-producing beta-cells. Accordingly, important research efforts aim at regenerating these lost beta-cells by converting pre-existing endogenous cells. Following up on previous results demonstrating the conversion of pancreatic somato...

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Wedi'i Gadw mewn:
Prif Awduron: Anna Garrido-Utrilla, Chaïma Ayachi, Marika Elsa Friano, Josipa Atlija, Shruti Balaji, Tiziana Napolitano, Serena Silvano, Noémie Druelle, Patrick Collombat
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2022-04-01
Cyfres:Frontiers in Endocrinology
Pynciau:
diabetes
somatostatin
pax4
gastrointestinal tract
mouse
Mynediad Ar-lein:https://www.frontiersin.org/articles/10.3389/fendo.2022.861922/full
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