Synergistic Regulation of Transcription and Translation in Escherichia coli Revealed by Codirectional Increases in mRNA Concentration and Translation Efficiency

ABSTRACT Translational regulation was investigated at the genome-scale in Escherichia coli cells. Using the polysome profiling method, the ribosome occupancy (RO) and ribosome density (RD) of different mRNA copies were determined for several hundred mRNAs during the exponential- and stationary-phase...

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Autori principali:	Huong Le Nguyen, Marie-Pierre Duviau, Sandrine Laguerre, Sébastien Nouaille, Muriel Cocaign-Bousquet, Laurence Girbal
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology 2022-02-01
Serie:	Microbiology Spectrum
Soggetti:	Escherichia coli gene expression regulation mRNA concentration polysome profiling ribosome density ribosome occupancy
Accesso online:	https://journals.asm.org/doi/10.1128/spectrum.02041-21
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