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Elucidating multifaceted targets of Marein in cerebral ischemia-reperfusion injury

BackgroundCerebral ischemia-reperfusion injury (CIRI) is a major pathological event in stroke, leading to neuronal damage and neuroinflammation. Marein, a flavonoid derived from Coreopsis tinctoria, has demonstrated potential neuroprotective effects, yet its precise mechanisms in CIRI remain unclear...

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Principais autores: Weidan Luo, Jian Wang, Ying Fan, Meng Yuan, Wanying Xie, Yang Su, Xingchun Wang, Yi Zhong, Yibo Zhang, Jiaxin Zhan, Xuan Mao, Xinyao Huang, Junxi Long, Xinrui Wang, Tingting Tang, Xingxia Wang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2025-10-01
coleção:Frontiers in Chemistry
Assuntos:
Marein
network pharmacology
cerebral ischemia-reperfusion injury
molecular docking
molecular dynamics simulation
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fchem.2025.1651873/full
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