Cell-free DNA from germline TP53 mutation carriers reflect cancer-like fragmentation patterns

Abstract Germline pathogenic TP53 variants predispose individuals to a high lifetime risk of developing multiple cancers and are the hallmark feature of Li-Fraumeni syndrome (LFS). Our group has previously shown that LFS patients harbor shorter plasma cell-free DNA fragmentation; independent of canc...

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Detalhes bibliográficos

Principais autores:	Derek Wong, Maha Tageldein, Ping Luo, Erik Ensminger, Jeffrey Bruce, Leslie Oldfield, Haifan Gong, Nicholas William Fischer, Brianne Laverty, Vallijah Subasri, Scott Davidson, Reem Khan, Anita Villani, Adam Shlien, Raymond H. Kim, David Malkin, Trevor J. Pugh
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2024-08-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-024-51529-w
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