Reduced intrinsic DNA curvature leads to increased mutation rate

Abstract Background Mutation rates vary across the genome. Many trans factors that influence mutation rates have been identified, as have specific sequence motifs at the 1–7-bp scale, but cis elements remain poorly characterized. The lack of understanding regarding why different sequences have diffe...

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Autori principali:	Chaorui Duan, Qing Huan, Xiaoshu Chen, Shaohuan Wu, Lucas B. Carey, Xionglei He, Wenfeng Qian
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2018-09-01
Serie:	Genome Biology
Soggetti:	DNA shape Intrinsic DNA curvature Mutation rate Mutational landscape Mutagen sensitivity
Accesso online:	http://link.springer.com/article/10.1186/s13059-018-1525-y
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