Microbial modulation of proteoglycan and glycosaminoglycan biosynthesis in a three-dimensional corneal epithelium model

BackgroundRecently, a three-dimensional in vitro corneal epithelium model, designated QobuR, was developed. This model aims to reproduce the complex cellular interactions observed in vivo and to provide an alternative to animal models for toxicity testing and ophthalmic drug development. However, th...

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Bibliografische Detailangaben

Hauptverfasser:	Noelia Blanco-Agudín, Francisco Pérez-Rastrollo, Natalia Vázquez, Suhui Ye, Cristina Sánchez-Fernández, María Daniela Corte-Torres, Jesús Merayo-Lloves, Iván Fernández-Vega, Luis M. Quirós
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2026-05-01
Schriftenreihe:	Frontiers in Cellular and Infection Microbiology
Schlagworte:	chondroitin sulfate corneal epithelium glycosaminoglycans heparan sulfate host–microbe interaction ocular surface
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fcimb.2026.1804227/full
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