E3 Ligase RNF126 Directly Ubiquitinates Frataxin, Promoting Its Degradation: Identification of a Potential Therapeutic Target for Friedreich Ataxia

Friedreich ataxia (FRDA) is a severe genetic neurodegenerative disease caused by reduced expression of the mitochondrial protein frataxin. To date, there is no therapy to treat this condition. The amount of residual frataxin critically affects the severity of the disease; thus, attempts to restore p...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Monica Benini, Silvia Fortuni, Ivano Condò, Giulia Alfedi, Florence Malisan, Nicola Toschi, Dario Serio, Damiano Sergio Massaro, Gaetano Arcuri, Roberto Testi, Alessandra Rufini
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2017-02-01
coleção:	Cell Reports
Assuntos:	Friedreich ataxia frataxin E3 ligase ubiquitin RNF126 protein degradation therapeutic target
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2211124717301493
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!