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Programming Bordetella pertussis lipid A to promote adjuvanticity

Abstract Background Bordetella pertussis is the causative agent of whooping cough or pertussis. Although both acellular (aP) and whole-cell pertussis (wP) vaccines protect against disease, the wP vaccine, which is highly reactogenic, is better at preventing colonization and transmission. Reactogenic...

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Principais autores: Yasmine Fathy Mohamed, Rachel C. Fernandez
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2024-09-01
Serier:Microbial Cell Factories
Fag:
Lipid A modification
Adjuvant
Vaccine
MPLA
Bordetella pertussis
Lipopolysaccharide
Online adgang:https://doi.org/10.1186/s12934-024-02518-7
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