Comparative Whole-Genomic Analysis of an Ancient L2 Lineage Mycobacterium tuberculosis Reveals a Novel Phylogenetic Clade and Common Genetic Determinants of Hypervirulent Strains

Background: Development of improved therapeutics against tuberculosis (TB) is hindered by an inadequate understanding of the relationship between disease severity and genetic diversity of its causative agent, Mycobacterium tuberculosis. We previously isolated a hypervirulent M. tuberculosis strain H...

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Autori principali:	Rahim Rajwani, Wing Cheong Yam, Ying Zhang, Yu Kang, Barry Kin Chung Wong, Kenneth Siu Sing Leung, Kingsley King Gee Tam, Ketema Tafess Tulu, Li Zhu, Gilman Kit Hang Siu
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2018-01-01
Serie:	Frontiers in Cellular and Infection Microbiology
Soggetti:	Mycobacterium tuberculosis hypervirulent macrophage Pacbio lineage2 comparative genomics
Accesso online:	http://journal.frontiersin.org/article/10.3389/fcimb.2017.00539/full
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