Analysis of complex chromosomal structural variants through optical genome mapping integrated with karyotyping

Background and ObjectiveParental chromosomal structural variations (SVs) represent a primary genetic factor contributing to recurrent spontaneous abortion (RSA). Individuals carrying SVs with complex chromosomal rearrangements (CCRs) typically exhibit a normal phenotype but are at an increased risk...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Xiaoxi Zhu, Huiling Zheng, Xue Wan, Hang Duan, Ying Qi, Weijia Tang, Fan Yang, Limei Yu
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2025-08-01
Schriftenreihe:	Frontiers in Genetics
Schlagworte:	recurrent spontaneous abortion structural variations chromosomal karyotype analysis optical genome mapping Kif7
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fgene.2025.1605461/full
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!