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Artificial intelligence-assisted optimization of Lentinula edodes extracts for enhanced bioactive profile and therapeutic potential

Abstract In this study, extraction parameters to increase the biological activities of Lentinula edodes extracts were optimized using both Response Surface Methodology (RSM) and Artificial Neural Network-Genetic Algorithm (ANN-GA) hybrid models. Antioxidant, anticholinesterase, antiproliferative act...

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Principais autores: Mustafa Sevindik, Vadim Tagirovich Khassanov, Ayşenur Gürgen, Ilgaz Akata
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2026-02-01
Serier:Scientific Reports
Fag:
Extraction optimization
Response surface methodology
Artificial neural network–genetic algorithm
Antioxidant activity
Anticholinesterase activity
Antiproliferative effect
Online adgang:https://doi.org/10.1038/s41598-026-41876-7
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