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N-Glycoengineering of insect cells for tri-antennary N-glycan biosynthesis

Abstract Insect cells are attractive hosts for biopharmaceutical production due to their high productivity and mammalian-like post-translational modifications. However, their insect-specific N-glycans differ from mammalian types, thereby reducing product desirability. Here, with an emphasis on engin...

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Autori principali: Hiroyuki Kajiura, Naokuni Nishiguchi, Reimi Lai Sang Sawada-Choi, Yuto Sana, Ryo Misaki, Kazuhito Fujiyama
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Portfolio 2026-03-01
Serie:Scientific Reports
Soggetti:
N-Glycosylation
Insect cells
N-Acetylglucosaminyltransferase IV
N-Acetylhexosaminidase
GlcNAc extension
Accesso online:https://doi.org/10.1038/s41598-026-41152-8
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