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The RNA-Binding Landscape of HAX1 Protein Indicates Its Involvement in Translation and Ribosome Assembly

HAX1 is a human protein with no known homologues or structural domains. Mutations in the <i>HAX1</i> gene cause severe congenital neutropenia through mechanisms that are poorly understood. Previous studies reported the RNA-binding capacity of HAX1, but the role of this binding in physiology and path...

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Principais autores: Anna Balcerak, Ewelina Macech-Klicka, Maciej Wakula, Rafal Tomecki, Krzysztof Goryca, Malgorzata Rydzanicz, Mateusz Chmielarczyk, Malgorzata Szostakowska-Rodzos, Marta Wisniewska, Filip Lyczek, Aleksandra Helwak, David Tollervey, Grzegorz Kudla, Ewa A. Grzybowska
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2022-09-01
coleção:Cells
Assuntos:
RNA–protein binding
HAX1
RIP-seq
CRAC
translation
ribosome assembly
Acesso em linha:https://www.mdpi.com/2073-4409/11/19/2943
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