Tryptophan metabolism in tumor microenvironment and therapeutic implications
Background: Tryptophan (Trp) catabolism has been recognized as a key immunosuppressive axis in cancer. However, this largely centered on indoleamine-2,3-dioxygenase 1 (IDO1). The clinical failure of IDO1 inhibitors has exposed the limitations of this reductionist view.Aim of Review: To re-synthesize...
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| Principais autores: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Elsevier
2026-09-01
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| Serier: | Journal of Advanced Research |
| Fag: | |
| Online adgang: | http://www.sciencedirect.com/science/article/pii/S2090123225010409 |
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