Central biogenic amine deficiency with concomitant exploratory behavioral deficits in Dnajc12 knock-out mice
Abstract Bi-allelic autosomal recessive pathogenic variants in DNAJC12 lead to a constellation of neurological features, including young-onset Parkinson’s disease. DNAJC12 is a co-chaperone for enzymes involved in biogenic amines synthesis. In vitro, we discovered overexpressed DNAJC12 forms a compl...
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| Hoofdauteurs: | , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Nature Portfolio
2025-05-01
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| Reeks: | npj Parkinson's Disease |
| Online toegang: | https://doi.org/10.1038/s41531-025-00991-4 |
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