Integrated post-GWAS, single-cell, and functional analyses prioritize TCTN2 at an osteoarthritis locus associated with innate immunity-related cartilage remodeling

BackgroundPost-genome-wide association study (GWAS) interpretation of osteoarthritis (OA) increasingly requires integration with single-cell biology because many risk loci likely act through sterile inflammatory remodeling, regulatory and inflammatory chondrocyte states, and tissue-stress biology ra...

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Autori principali:	Changchun Lu, Lei Wang, Xinqi Cao, Kun Zhao, Nuo Yin, Dong Zhang
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2026-07-01
Serie:	Frontiers in Immunology
Soggetti:	chondrocyte hypertrophy innate immunity osteoarthritis single-cell RNA sequencing TCTN2
Accesso online:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1883412/full
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