Disease Modeling on Tumor Organoids Implicates AURKA as a Therapeutic Target in Liver Metastatic Colorectal CancerSummary

Background & Aims: Patient-derived tumor organoids recapitulate the characteristics of colorectal cancer (CRC) and provide an ideal platform for preclinical evaluation of personalized treatment options. We aimed to model the acquisition of chemotolerance during first-line combination chemotherap...

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Autors principals:	Sophie L. Boos, Leon P. Loevenich, Sebastian Vosberg, Thomas Engleitner, Rupert Öllinger, Jörg Kumbrink, Matjaz Rokavec, Marlies Michl, Philipp A. Greif, Andreas Jung, Heiko Hermeking, Jens Neumann, Thomas Kirchner, Roland Rad, Peter Jung
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2022-01-01
Col·lecció:	Cellular and Molecular Gastroenterology and Hepatology
Matèries:	Cetuximab FOLFIRI Chemoresistance KRAS CRC Organoid
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2352345X21002228
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