Distribution of age at natural menopause, age at menarche, menstrual cycle length, height and BMI in BRCA1 and BRCA2 pathogenic variant carriers and non-carriers: results from EMBRACE

Abstract Background Carriers of germline pathogenic variants (PVs) in the BRCA1 and BRCA2 genes are at higher risk of developing breast and ovarian cancer than the general population. It is unclear if these PVs influence other breast or ovarian cancer risk factors, including age at menopause (ANM),...

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Principais autores:	Nasim Mavaddat, Debra Frost, Emily Zhao, Daniel R. Barnes, Munaza Ahmed, Julian Barwell, Angela F. Brady, Paul Brennan, Hector Conti, Jackie Cook, Harriet Copeland, Rosemarie Davidson, Alan Donaldson, Emma Douglas, David Gallagher, Rachel Hart, Louise Izatt, Zoe Kemp, Fiona Lalloo, Zosia Miedzybrodzka, Patrick J. Morrison, Jennie E. Murray, Alex Murray, Hannah Musgrave, Claire Searle, Lucy Side, Katie Snape, Vishakha Tripathi, Lisa Walker, Stephanie Archer, D. Gareth Evans, Marc Tischkowitz, Antonis C. Antoniou, Douglas F. Easton
格式:	Artigo
語言:	Inglês
出版:	BMC 2025-05-01
叢編:	Breast Cancer Research
主題:	BRCA1 BRCA2 Menopause Menarche Height Body mass index
在線閱讀:	https://doi.org/10.1186/s13058-025-02030-9
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