Single-cell transcriptional profile of CD34+ hematopoietic progenitor cells from del(5q) myelodysplastic syndromes and impact of lenalidomide

Abstract While myelodysplastic syndromes with del(5q) (del(5q) MDS) comprises a well-defined hematological subgroup, the molecular basis underlying its origin remains unknown. Using single cell RNA-seq (scRNA-seq) on CD34+ progenitors from del(5q) MDS patients, we have identified cells harboring the...

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Hlavní autoři:	Guillermo Serrano, Nerea Berastegui, Aintzane Díaz-Mazkiaran, Paula García-Olloqui, Carmen Rodriguez-Res, Sofia Huerga-Dominguez, Marina Ainciburu, Amaia Vilas-Zornoza, Patxi San Martin-Uriz, Paula Aguirre-Ruiz, Asier Ullate-Agote, Beñat Ariceta, Jose-Maria Lamo-Espinosa, Pamela Acha, Oriol Calvete, Tamara Jimenez, Antonieta Molero, Maria Julia Montoro, Maria Díez-Campelo, David Valcarcel, Francisco Solé, Ana Alfonso-Pierola, Idoia Ochoa, Felipe Prósper, Teresa Ezponda, Mikel Hernaez
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2024-06-01
Edice:	Nature Communications
On-line přístup:	https://doi.org/10.1038/s41467-024-49529-x
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