COL22A1 expression identifies aggressive glioma and independently predicts survival through integrated multiomics and clinical validation

Abstract Background Gliomas, especially IDH‑wildtype astrocytomas, remain lethal despite multimodal therapy. Collagen type XXII alpha-1 (COL22A1) exhibits oncogenic activity in other cancers but remains underexplored in brain tumors. We asked whether its expression, cellular origin, and spatial cont...

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Hlavní autoři:	Wei-Wen Hsu, Wen-Shin Song, Pei-Chi Chang, Dueng-Yuan Hueng, Yao-Feng Li
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Springer 2025-10-01
Edice:	Discover Oncology
Témata:	COL22A1 Glioblastoma TCGA CGGA GSEA Single-cell sequencing
On-line přístup:	https://doi.org/10.1007/s12672-025-03723-5
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