SURGE: uncovering context-specific genetic-regulation of gene expression from single-cell RNA sequencing using latent-factor models

Abstract Genetic regulation of gene expression is a complex process, with genetic effects known to vary across cellular contexts such as cell types and environmental conditions. We developed SURGE, a method for unsupervised discovery of context-specific expression quantitative trait loci (eQTLs) fro...

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Bibliographic Details

Main Authors:	Benjamin J. Strober, Karl Tayeb, Joshua Popp, Guanghao Qi, M. Grace Gordon, Richard Perez, Chun Jimmie Ye, Alexis Battle
Format:	Artigo
Language:	Inglês
Published:	BMC 2024-01-01
Series:	Genome Biology
Subjects:	eQTL Single-cell transcriptomics
Online Access:	https://doi.org/10.1186/s13059-023-03152-z
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