High-efficiency targeted editing of large viral genomes by RNA-guided nucleases.
A facile and efficient method for the precise editing of large viral genomes is required for the selection of attenuated vaccine strains and the construction of gene therapy vectors. The type II prokaryotic CRISPR-Cas (clustered regularly interspaced short palindromic repeats (CRISPR)-associated (Ca...
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| Principais autores: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science (PLoS)
2014-05-01
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| coleção: | PLoS Pathogens |
| Acesso em linha: | https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004090&type=printable |
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