Disruption of VEGF Mediated Flk‐1 Signaling Leads to a Gradual Loss of Vessel Health and Cardiac Function During Myocardial Infarction: Potential Therapy With Pellino‐1

Background The present study demonstrates that the ubiquitin E3 ligase, Pellino‐1 (Peli1), is an important angiogenic molecule under the control of vascular endothelial growth factor (VEGF) receptor 2/Flk‐1. We have previously reported increased survivability of ischemic skin flap tissue by adenovir...

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Hlavní autoři:	Mahesh Thirunavukkarasu, Vaithinathan Selvaraju, Mandip Joshi, Vladimir Coca‐Soliz, Leonidas Tapias, IbnalWalid Saad, Craig Fournier, Aaftab Husain, Jacob Campbell, Siu‐Pok Yee, Juan A. Sanchez, J. Alexander Palesty, David W. McFadden, Nilanjana Maulik
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Wiley 2018-09-01
Edice:	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Témata:	adenovirus animal models gene therapy genetics myocardial infarction myocardial revascularization
On-line přístup:	https://www.ahajournals.org/doi/10.1161/JAHA.117.007601
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