Inhibition of estrogen receptor alpha stabilizes regulatory T cell function in autoimmune hepatitis

Background & Aims: Regulatory T cell (Treg) dysfunction is a hallmark of autoimmune hepatitis (AIH), a serious hepatopathy often progressing to end-stage liver disease despite immunosuppression. Treg impairment in AIH has been linked to defective signaling through the aryl hydrocarbon receptor (...

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Principais autores:	Lina Zhang, Barbora Gromova, Du Hanh Nguyen, Cortney Cagle, Graziela S. Gomes, William Li, Li Gao, Wei Zhang, Jonathon J. Graham, Na Wang, Ahmadreza Kalbasi, Eva Csizmadia, Angelina Wei, Jessica Cassavaugh, Alan Bonder, Vilas Patwardhan, Sizun Jiang, Satya K. Kota, Maria Serena Longhi
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2026-02-01
Series:	JHEP Reports
Assuntos:	autoimmune hepatitis regulatory T cells estrogen receptor-alpha hypoxia-inducible factor 1-alpha
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2589555925003611
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