Substrate spectrum of PPM1D in the cellular response to DNA double-strand breaks
Summary: PPM1D is a p53-regulated protein phosphatase that modulates the DNA damage response (DDR) and is frequently altered in cancer. Here, we employed chemical inhibition of PPM1D and quantitative mass spectrometry-based phosphoproteomics to identify the substrates of PPM1D upon induction of DNA...
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| Huvudupphov: | , , , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Utgiven: |
Elsevier
2022-09-01
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| Serie: | iScience |
| Ämnen: | |
| Länkar: | http://www.sciencedirect.com/science/article/pii/S2589004222011646 |
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