Novel adenovirus vaccine vectors lacking thrombosis-associated interactions with platelet factor 4

Summary: The adenoviral vector-based AstraZeneca and Janssen COVID-19 vaccines have been associated with rare cases of thrombosis, believed to be triggered, among other factors, by vector binding to the blood protein platelet factor 4 (PF4). To identify vectors with lower thrombosis risk, we screene...

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Auteurs principaux:	Erwan Sallard, Daniel Pembaur, Matias Ciancaglini, Lucie Manov-Bouard, Denice Weklak, Firas Hamdan, Chun Kit Chan, Franziska Jönsson, Elise Chabot, Carmen Musielak, Elena Scurti, Sara Feola, Sebastian Schellhorn, Nissai Beaude, Katrin Schröer, Daipayan Sarkar, Georgia Koukou, Xiaoyan Wang, Natascha Schmidt, Wibke Bayer, Malik Aydin, Vera Kemp, Alan L. Parker, Dirk Grimm, Tapani Viitala, Vincenzo Cerullo, Abhishek Singharoy, Alexander T. Baker, Wenli Zhang, Daniel Pinschewer, Florian Kreppel, Anja Ehrhardt
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2026-01-01
Collection:	iScience
Sujets:	Molecular biology Immune response
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S2589004225025908
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