Aging, Rather than Genotype, Is the Principal Contributor to Differential Gene Expression Within Targeted Replacement APOE2, APOE3, and APOE4 Mouse Brain

<b>Background:</b> Apolipoprotein E (APOE) is the strongest genetic risk determinant for late-onset Alzheimer’s disease (AD). The APOE3 allele is risk-neutral, the APOE4 allele increases the risk of developing AD, and the APOE2 allele is neuroprotective. <b>Methods</b>: We utilized RNA sequencing of...

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Hlavní autoři:	Amanda Labuza, Harshitha Pidikiti, Melissa J. Alldred, Kyrillos W. Ibrahim, Katherine Y. Peng, Jonathan Pasato, Adriana Heguy, Paul M. Mathews, Stephen D. Ginsberg
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2025-10-01
Edice:	Brain Sciences
Témata:	apolipoprotein E aging Alzheimer’s disease neurodegeneration mouse model RNA sequencing
On-line přístup:	https://www.mdpi.com/2076-3425/15/10/1117
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