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Alveolar type II epithelial cell FASN maintains lipid homeostasis in experimental COPD

Alveolar epithelial type II (AEC2) cells strictly regulate lipid metabolism to maintain surfactant synthesis. Loss of AEC2 cell function and surfactant production are implicated in the pathogenesis of the smoking-related lung disease chronic obstructive pulmonary disease (COPD). Whether smoking alte...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Li-Chao Fan, Keith McConn, Maria Plataki, Sarah Kenny, Niamh C. Williams, Kihwan Kim, Jennifer A. Quirke, Yan Chen, Maor Sauler, Matthias E. Möbius, Kuei-Pin Chung, Estela Area Gomez, Augustine M.K. Choi, Jin-Fu Xu, Suzanne M. Cloonan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical investigation 2023-08-01
Schriftenreihe:JCI Insight
Schlagworte:
Metabolism
Pulmonology
Online-Zugang:https://doi.org/10.1172/jci.insight.163403
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