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OVEREXPRESSION/KNOCKDOWN OF ADAPTOR PROTEIN Ruk/CIN85 IN HUMAN LUNG ADENOCARCINOMA A549 CELLS RESULTS IN OPPOSITE CHANGES BETWEEN MMP-2/MMP-9 EXPRESSION LEVELS/ACTIVITIES AND CELL`S INVASION

Aim. To investigate the changes in MMPs expression and activity as well as invasiveness of human lung adenocarcinoma A549 cells with up-/down-regulation of Ruk/CIN85. Methods. There were used A549 cells with stable overexpression (subline RukUp) and knockdown of Ruk/CIN85 (subline RukDown), as we...

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Gespeichert in:
Hauptverfasser: M.I. BEKALA, D.S. GERASCHENKO, O.V. KHUDIAKOVA, T.D. SKATERNA
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry 2023-04-01
Schriftenreihe:Biotechnologia Acta
Schlagworte:
lung adenocarcinoma
motility
invasion
epithelial-mesenchymal transition
mmps
adaptor protein ruk/cin85.
Online-Zugang:https://biotechnology.kiev.ua/images/BTA/2023/2_2023/Bekala_2_2023.pdf
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