Norovirus evolution in immunodeficient mice reveals potentiated pathogenicity via a single nucleotide change in the viral capsid.

Interferons (IFNs) are key controllers of viral replication, with intact IFN responses suppressing virus growth and spread. Using the murine norovirus (MNoV) system, we show that IFNs exert selective pressure to limit the pathogenic evolutionary potential of this enteric virus. In animals lacking ty...

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Hlavní autoři:	Forrest C Walker, Ebrahim Hassan, Stefan T Peterson, Rachel Rodgers, Lawrence A Schriefer, Cassandra E Thompson, Yuhao Li, Gowri Kalugotla, Carla Blum-Johnston, Dylan Lawrence, Broc T McCune, Vincent R Graziano, Larissa Lushniak, Sanghyun Lee, Alexa N Roth, Stephanie M Karst, Timothy J Nice, Jonathan J Miner, Craig B Wilen, Megan T Baldridge
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Public Library of Science (PLoS) 2021-03-01
Edice:	PLoS Pathogens
On-line přístup:	https://doi.org/10.1371/journal.ppat.1009402
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