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OGG1 and MUTYH DNA Glycosylases, the Dynamic Duo Against 8-Oxoguanine DNA Lesion: Structure, Regulation, and Novel Emerging Roles

OGG1 and MUTYH are base excision repair (BER) DNA glycosylases (DGs) from the Helix–hairpin–Helix superfamily responsible for initiating and coordinating the repair of 8-oxo-7,8-dihydroguanine (OG), and its replication-derived mispair with adenine (OG:A), respectively. The DNA repair activities of t...

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Principais autores: Ana P. Gómez-Ramírez, Melody Malek, Estela G. García-González, Sergio E. Campos, Luis G. Brieba, Sheila S. David, Carlos H. Trasviña-Arenas
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2026-02-01
Serier:Biomolecules
Fag:
oxidative DNA damage
DNA glycosylase
MUTYH
OGG1
DNA repair
Online adgang:https://www.mdpi.com/2218-273X/16/2/257
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