Structural basis of the regulation by CDK11 kinase of early spliceosome activation and evidence for its proofreading by DHX15 helicase

Abstract Formation of the activated human spliceosome (Bact) involves major structural rearrangements, leading to the catalytically active U2/U6 RNA core. This process involves at least two intermediates, pre-Bact-1 and pre-Bact-2, and is regulated by CDK11-mediated phosphorylation of the U2 snRNP p...

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Autors principals:	Zhenwei Zhang, Vinay Kumar, Sumeru Panta, Jiayun Zhong, Olexandr Dybkov, Haohao Dong, Berthold Kastner, Henning Urlaub, Holger Stark, Reinhard Lührmann
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2026-07-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-026-75109-2
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