Inhibition of the Activin Receptor Type-2B Pathway Restores Regenerative Capacity in Satellite Cell-Depleted Skeletal Muscle

Degenerative myopathies typically display a decline in satellite cells coupled with a replacement of muscle fibers by fat and fibrosis. During this pathological remodeling, satellite cells are present at lower numbers and do not display a proper regenerative function. Whether a decline in satellite...

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Detalhes bibliográficos

Principais autores:	Luigi Formicola, Alice Pannérec, Rosa Maria Correra, Barbara Gayraud-Morel, David Ollitrault, Vanessa Besson, Shahragim Tajbakhsh, Jennifer Lachey, Jasbir S. Seehra, Giovanna Marazzi, David A. Sassoon
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2018-05-01
coleção:	Frontiers in Physiology
Assuntos:	muscle atrophy muscle regeneration muscle stem cell niche satellite cells TGFβ signaling
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fphys.2018.00515/full
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