FAAP100 is required for the resolution of transcription-replication conflicts in primordial germ cells

Abstract Background The maintenance of genome stability in primordial germ cells (PGCs) is crucial for the faithful transmission of genetic information and the establishment of reproductive reserve. Numerous studies in recent decades have linked the Fanconi anemia (FA) pathway with fertility, partic...

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Detalhes bibliográficos

Principais autores:	Weiwei Xu, Yajuan Yang, Yongze Yu, Canxin Wen, Simin Zhao, Lili Cao, Shidou Zhao, Yingying Qin, Zi-Jiang Chen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2023-08-01
coleção:	BMC Biology
Assuntos:	Primordial germ cells FAAP100 Genome stability Transcription-replication conflicts R-loop
Acesso em linha:	https://doi.org/10.1186/s12915-023-01676-1
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